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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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Yohimbine is a naturally occurring alkaloid first identified by American botanist R. Raymond Hamet in 1934 in several herbal species. Its main sources are the bark of an African evergreen tree called Pausinystalia Yohimbe and the Indian snakeroot Rauwolfia serpentina. With its discrete molecular structure and known receptor binding yohimbine is commonly investigated in experimentally oriented pharmacological & biochemical studies.
At the mechanistic level, yohimbine acts as a specific antagonist of presynaptic αâ‚‚-adrenergic receptors and changes neurotransmitter release profiles under strict experimental settings. Aside from adrenergic signaling, it has been investigated for interaction with serotonergic and dopaminergic receptor systems as well as effects on nitric oxide–mediated signaling pathways, in cellular and molecular models. These characteristics render yohimbine a useful tool to investigate neurochemical regulation, vascular signaling cascades and intracellular signaling pathways. At Element CRP, yohimbine for sale is supplied exclusively for laboratory, analytical, and educational research purposes and is not intended for human or animal use, ingestion, or therapeutic application.
From Pubchem
IUPAC Name:methyl (1S,15R,18S,19R,20S)-18-hydroxy-1,3,11,12,14,15,16,17,18,19,20,21-dodecahydroyohimban-19-carboxylateSynonym: Yohimbine, Quebrachin, QuebrachineMolecular Formula: C21H26N2O3Molecular Weight: 354.4 g/molCAS Number: 146-48-5PubChem CID: 8969
Yohimbine is widely used as an experimental pharmacological tool for investigating presynaptic and postsynaptic α2-adrenergic signaling, where it functions as a reference antagonist for α2-adrenergic receptors. In controlled laboratory settings, α2-receptor antagonism alters norepinephrine release by disrupting receptor-mediated negative feedback mechanisms, modifies temporal patterns of noradrenaline signaling, and activates downstream second-messenger cascades. These properties support its use as a model compound for studying neurotransmitter regulation, receptor desensitization, and short-term synaptic signaling plasticity.
In isolated cellular and tissue systems, α2-adrenergic receptor antagonism has been associated with modulation of intracellular cyclic nucleotide signaling pathways, including cAMP- and cGMP-dependent mechanisms and nitric oxide–related signal transduction. These characteristics make yohimbine a useful probe for examining adrenergic receptor coupling, smooth muscle signal integration, and neurovascular communication within preclinical research frameworks.
Within metabolic research contexts, yohimbine has been utilized to evaluate α2-adrenergic receptor function in adipocyte signaling and lipid mobilization systems. α2-receptor blockade modifies catecholamine-mediated inhibition of lipolytic enzymes, enabling investigation of adrenergic regulation of triglyceride hydrolysis and fatty acid flux in controlled in vitro and ex vivo models.
Experimental paradigms examining appetite-related neurotransmitter signaling and central–peripheral metabolic interfaces have also incorporated yohimbine. These studies emphasize receptor-level regulation and molecular signaling dynamics rather than physiological outcomes, contributing to an expanded understanding of adrenergic involvement in energy balance at the cellular level.
Yohimbine has been applied in mechanistic studies exploring interactions between adrenergic signaling and inflammatory mediators, including investigations of neurocardiac communication pathways. α2-adrenergic receptors participate in regulating catecholamine release during inflammatory processes, and receptor antagonists such as yohimbine serve as molecular tools for dissecting these signaling interactions.
Experimental data indicate that α2-adrenergic modulation can influence endothelial signaling, nitric oxide production, and intracellular stress-response cascades in isolated cardiac and vascular preparations. These observations support its use for studying receptor-dependent signaling modulation without implying functional or biological outcomes.
Beyond adrenergic systems, yohimbine exhibits affinity for multiple G-protein–coupled receptors, including certain dopamine and serotonin receptor subtypes. This receptor promiscuity has supported its use as a scaffold compound in structure–activity relationship studies examining GPCR cross-reactivity and signaling bias.
Structural derivatives of the yohimbine backbone have been synthesized and evaluated for antagonist activity across additional GPCR families, including oxytocin and vasopressin receptors. These investigations contribute to receptor-mapping and molecular pharmacology research focused on signal transduction diversity and transcriptional regulation, without clinical or therapeutic interpretation.
Yohimbine is an indole alkaloid widely employed in laboratory research as a non-selective α2-adrenergic receptor antagonist and GPCR interaction probe. Its established receptor-binding characteristics support its use in studies of neurotransmitter regulation, metabolic signaling, inflammatory pathways, and receptor cross-talk at the molecular level.
Yohimbine remains an experimental research compound with no approved therapeutic or medical application. Yohimbine for sale by Element CRP is intended strictly for laboratory, analytical, and educational research use and is not approved for human or animal consumption. Buy Yohimbine if you are a qualified researcher.
Yohimbine is a small-molecule indole alkaloid functioning as a selective alpha-2 adrenergic receptor antagonist. Its stable structure in solution supports reliable behaviour in standard cell culture buffer systems used for adrenergic receptor pharmacology research.
Cell-based research with Yohimbine examines selective a2-AR antagonism with downstream effects on Gai/cAMP coupling and norepinephrine release pathway modulation in adrenergic cell line models. Standard readouts include receptor binding displacement assays, cAMP measurement, and comparative pharmacology against other a-AR ligands.
Element CRP supplies this product at 10mg/mL × 30mL. USA-manufactured via chemical synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Pre-mixed liquid solution in 30mL or 60mL bottle with dropper; ready for laboratory use. Store at 15-25°C, away from direct light.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
