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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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For this product you will need: BACTERIOSTATIC WATER For reconstitution.
TB-500 has synthetic origins and it is an analogue of the naturally conserved peptide Thymosin Beta-4 (Tβ4) present in all eukaryotic cells. Thymosin Beta-4 acts as a regulator of various cellular functions such as cytoskeletal organization, cell motility, angiogenesis, and extracellular matrix modification. It is composed of 43 amino acid residues and can be found in number of tissues and bodily fluids such as blood, saliva or wound exudate. TB-500 is a synthetic derivative of Tβ4, a molecular clone of the native Tβ4 in structure that has been developed for experimental use in order to examine actin dynamics and also to ascertain the mechanisms of cellular migration and cell signaling pathways [1].
Thymosin Beta-4 was initially characterized and isolated from bovine thymus tissue in the 1980s. The synthetic analogue TB-500 was subsequently developed in 2010 for laboratory research applications. TB-500 is supplied exclusively for educational and experimental purposes and is intended solely for controlled scientific investigation. On our website, TB-500 for sale is restricted to qualified researchers and is not intended for human or animal use.
From Pubchem
Synonyms: QHK6Z47GTG, TB-500Molecular Formula: C38H68N10O14Molecular Weight: 889.0 g/molSequence: LKKTETQCAD Number: 885340-08-9PubChem CID: 62707662
TB-500, a synthetic derivative of Thymosin Beta-4 (Tβ4), is used to study the molecular pathways associated with angiogenesis. In such an experimental scenario Tβ4 is able to modify the endothelial cell function, changing fibroblast transformation and the cytoskeletal organization related to angiogenesis [2].
Experimental models have elucidated the involvement of AKT and PI3Kα/Rho signaling pathways in mediating actin-dependent cellular migration and structural reorganization. Inhibition of these pathways attenuates endothelial network formation, highlighting the role of Tβ4 as a tool for dissecting intracellular signaling cascades relevant to vessel morphogenesis [3].
TB-500 is used in research laboratory experiments to investigate actin cellular processes within muscle cells. Studies target modification of myofibrillar structure, cytoskeletal reorganization and actin filament dynamics. Tβ4 enhances cell motility and differentiation responses in model tissue systems, enabling experimental tools with which to probe of the mechanisms underlying structural organization in muscle [4,5].
Tβ4 is applied in research to analyze wound microenvironment remodeling and extracellular matrix dynamics. Experimental systems demonstrate that TB-500 regulates actin polymerization, stem cell migration, and differentiation, as well as matrix metalloproteinase expression, thereby influencing structural organization within model tissue constructs [6,7,9]. These properties make TB-500 a valuable reagent for mechanistic investigation of cytoskeletal regulation and morphogenetic pathways.
Thymosin Beta-4 is used experimentally to study epithelial cell migration, extracellular matrix organization, and tissue repair processes in ocular surface models. Laboratory research highlights its effect on corneal epithelial cell motility, junctional protein distribution, and modulation of cytoskeletal networks under defined conditions [10,11].
TB-500 functions as a research-grade synthetic analogue of Thymosin Beta-4, employed exclusively for mechanistic studies of actin dynamics, cellular migration, angiogenic signaling, and tissue morphogenesis. It is not intended for clinical or human use. TB-500 for sale is available strictly for laboratory and educational research purposes and should be purchased only by qualified investigators.
TB-500 is a synthetic peptide fragment corresponding to the active region of thymosin beta-4, a naturally occurring actin-sequestering protein. Its compact structural format is designed for stability in cell culture media and tolerance of standard freeze-thaw cycles, making it a practical tool for cell-based assay protocols requiring consistent compound activity across prolonged experimental windows.
Cell-based research using TB-500 examines its interaction with G-actin monomers via the conserved actin-binding domain, with downstream effects on cytoskeletal reorganisation and integrin-mediated cell adhesion in fibroblast and endothelial cell models. Published in vitro studies further characterise its modulation of matrix metalloproteinase expression patterns, particularly MMP-2 and MMP-9, in cell migration and wound-healing assay formats.
Element CRP supplies this product at 5mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
