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Tamoxifen is a selective estrogen receptor modulator (SERM) with both agonist and antagonist effects in tissue-specific signaling contexts. It is known to cross-talk with estrogen receptor signalling endogenous agonists that affect transcriptional regulation, gene expression and intracellular signaling pathways. Tamoxifen is also identified as an activator of heat shock protein 90 (Hsp90) in that the drug stimulates Hsp90s ATPase activity, which leads to chaperones mediated folding and stabilization processes.
Tamoxifen was synthesized initially in 1962 and has since been commonly used within laboratory research to investigate receptor–ligand interactions, signalling transduction and pathway manipulation. Its molecular properties are utilized as a probe for receptor specificity, transcriptional regulation and downstream intracellular signaling.
At Element CRP, liquid tamoxifen for sale is supplied exclusively for research and educational purposes. The compound is intended strictly for laboratory investigation and is not approved for human or animal use, ingestion, or application in food, drug, or cosmetic products.
From Pubchem
IUPAC Name:2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamineSynonyms: trans-Tamoxifen, Crisafeno, DiemonMolecular Formula: C26H29NOMolecular Weight: 371.5 g/molCAS Number: 10540-29-1PubChem CID: 2733526
Tamoxifen is often used as a research tool to specifically activate estrogen receptor-dependent processes, especially in studies of the role of estrogens in gene expression and as reportergene systems. It acts on estrogen receptor alpha (ERα)–dependent pathways and affects subsequent signaling, such as on PI3K/Akt pathway switching and PTEN-related regulation. Studies investigate the impact on intracellular transcriptional responses to receptor activation, inhibition or cross-talk with other molecular pathways.
Studies also focus on the role of extracellular vesicles and exosome signaling as well as microRNA crosstalk in receptor availability and pathway dynamics. These investigations address molecular processes, receptor sensitivity, and the interplay of intracellular signaling rather than functional measures.
Tamoxifen is used as a molecular tool for examining reproductive hormone–regulated signaling pathways. Its effect on gonadotropin action, steroidogenic enzyme activity and feedback regulation in hormone-responsive systems is reviewed.
Experimental models have also been developed to assess the effects of tamoxifen on gametogenesis-related cellular pathways such as spermatogenesis-related signaling and regulation of ovary-analogy pathways in in vitro or ex vivo systems. These studies focus on receptor-ligand binding, transcriptional regulation and intracytoplasmic signal transduction not reproductive outcomes.
Tamoxifen is employed in studies to reveal estrogen receptor–dependent signaling within hormone sensitive tissues. Work includes receptor agonist and antagonist profiling, cell type specific transcriptional modulation and downstream kinase and co-chaperone interactions. Molecular studies involve the effects of tamoxifen on heat shock protein 90 (Hsp90) ATPase activity, chaperone-assisted folding and integration into intracellular signaling networks.
Tamoxifen has been the subject of molecular tool in research regarding myotubularin- related processes such as phosphoinositide metabolism and intracellular vesicle trafficking. Studies emphasize transcriptional regulation, kinase signaling networks, and the modulation of molecular pathways in muscle-relevant cellular systems. Studies focus on receptor mediated pathway crosstalk, signal transduction and molecular adaptation; not on functional or physiological level.
Tamoxifen is a nonsteroidal selective estrogen receptor modulator that has been used as molecular tool in laboratory investigation of the dynamics of receptor-ligand interactions, transcription and intracellular signaling. Current research explores its role in estrogen receptor–mediated pathways, Hsp90 activity, and myotubularin-associated signaling networks.
At Element CRP, liquid tamoxifen is supplied exclusively for research and educational purposes. The compound is not intended for human or animal use, ingestion, or application in food, drug, or cosmetic products.
Tamoxifen is a small-molecule selective estrogen receptor modulator (SERM) with a triphenylethylene structure delivering tissue-selective estrogen receptor antagonist or partial agonist behaviour depending on cellular context. The compound shows excellent stability in standard cell culture media used for nuclear receptor pharmacology research.
Cell-based research with Tamoxifen examines estrogen receptor (ER-alpha and ER-beta) binding and downstream transcriptional regulation in MCF-7, T-47D, and other ER-positive cell line backgrounds. Standard readouts include ERE-driven luciferase reporter assays, ERa coactivator recruitment studies, and comparative pharmacology against other SERMs in nuclear receptor research.
Element CRP supplies this product at 20mg/mL × 30mL. USA-manufactured via chemical synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Pre-mixed liquid solution in 30mL or 60mL bottle with dropper; ready for laboratory use. Store at 15-25°C, away from direct light.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
