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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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Andarine, also known as S4 is a non-steroidal selective androgen receptor modulator (SARM). It has been produced and studied in laboratory settings to see whether its affinity for the androgen receptor, as well as its capacity to modulate receptor-mediated transactivation could be experimentally controlled.
Chemically and molecularly, S4 is used as a lead compound for research into androgen receptor onselectivity, ligand–receptor interactions, and downstream signaling pathways. Its non-steroidal structure enables investigators to study receptor activation mechanisms and structure–activity relationships that differ from those of classical steroidal compounds.
S4 remains an investigational substance and is not approved by the U.S. Food and Drug Administration for therapeutic, diagnostic, or clinical use. Any Andarine (S4) supplied by Element CRP is intended exclusively for laboratory and educational research purposes. The compound is not meant for human or animal consumption or as a component of food, drug and cosmetic products. Access to buy S4 limited to qualified researchers approved by ethical and regulatory guidelines.
From Pubchem
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IUPAC Name: (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamideSynonyms: 401900-40-1, GTX-007, S-4 cpd Molecular Formula: C19H18F3N3O6Molecular Weight: 441.4 g/mol CAS number: 401900-40-1PubChem CID: 9824562
Andarine (S4) has been studied as a non-steroidal ligand with tissue-selective activity on androgen receptor (AR) domains in controlled laboratory settings. Pharmacological investigations examine its capacity to induce receptor conformational changes distinct from those associated with steroidal agonists. These conformational differences influence the recruitment of co-activators and co-repressors, enabling detailed analysis of tissue-selective androgen receptor signaling at the molecular level.
Comparative structure–activity relationship (SAR) analyses have utilized Andarine as a benchmark compound to identify differential androgen receptor activation across anabolic and androgenic target tissues. Such investigations focus on receptor occupancy, transcriptional modulation, and downstream gene expression profiles under isolated experimental conditions.
In vitro and mechanistic research has explored the interaction of S4 with androgen receptor–mediated metabolic signaling networks. These studies evaluate transcriptional regulation of lipid metabolism, mitochondrial function, and energy-related gene clusters, without attributing systemic or physiological outcomes.
S4 is frequently used as a chemical research tool to examine how selective androgen receptor ligands influence metabolic gene expression patterns, intracellular signaling pathways, and nuclear receptor cross-talk under controlled laboratory conditions.
Research involving S4 includes investigation of androgen receptor–dependent pathways associated with skeletal matrix turnover and mineralization signaling. Laboratory studies assess how AR–ligand interactions affect osteogenic and osteoclastic gene markers, extracellular matrix remodeling signals, and transcription factors involved in bone-associated cellular pathways.
These investigations aim to clarify receptor-mediated modulation of structural protein expression and mineral homeostasis at the cellular and molecular level, independent of clinical or physiological interpretation.
Cell-based research has evaluated S4 as a tool for studying androgen receptor involvement in cell cycle regulation and intracellular signaling cascades. Experimental models examine interactions with pathways governing cell cycle checkpoints, transcriptional repressors, and growth-regulatory signaling nodes such as PI3K/AKT/mTOR.
These analyses are limited to mechanistic observations of pathway modulation, gene expression regulation, and intracellular signaling behavior within isolated research systems.
Andarine (S4) is an investigational research compound that has not been approved by the FDA for therapeutic, diagnostic, or clinical use. No claims are made regarding biological outcomes, safety, or suitability for any purpose outside controlled laboratory research.
At Element CRP, Andarine (S4) for sale is supplied exclusively for educational and research purposes. The compound is not approved for human or animal consumption and is not included in any food, drug, or cosmetic product. Access to buy Andarine (S4) are restricted to qualified researchers operating in accordance with applicable regulatory and ethical standards.
S4 (Andarine) is a non-steroidal small-molecule selective androgen receptor modulator featuring an aryl-propionamide scaffold that delivers tissue-selective AR engagement. Its solution stability supports reliable performance in standard cell culture systems used for AR pharmacology research.
Cell-based research with S4 Andarine examines partial AR agonist activity, tissue-selective transcriptional regulation, and comparative pharmacology against other SARM compounds in muscle and bone cell models. Standard readouts include AR-driven reporter assays, coactivator recruitment profiling, and target gene expression analysis.
Element CRP supplies this product at 50mg/mL × 30mL. USA-manufactured via chemical synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Pre-mixed liquid solution in 30mL or 60mL bottle with dropper; ready for laboratory use. Store at 15-25°C, away from direct light.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
