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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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Bremelanotide, also known as PT-141, is an analogue of synthetic peptide and it corresponds structurally to melanotan-based compounds that in turn were derived from some modifications of endogenous melanocortin peptides. PT-141 is synthetic peptide which binds to multiple melanocortin receptor subtypes, including MC4R, which has been the focus of much investigation due to its role in intracellular signalling and receptor-mediated biological behaviours.
PT-141 is a heptapeptide that first appeared in scientific literature in the early 2000s. And subsequent studies have been mainly concentrate on its molecular structure, receptor-binding properties and interaction with signaling pathways in vitro. PT-141 is for research and laboratory use only to be used by trained professionals. PT-141 is available exclusively for educational and laboratory research purposes and is not approved for clinical, therapeutic, or diagnostic use.
From Pubchem
Synonyms: Bremelanotide, PT-141Molecular Formula: C50H68N14O10Molecular Weight: 1025.2 g/molCAD Number: 189691-06-3PubChem CID: 9941379
PT-141 (bremelanotide) is a synthetic analogue of melanocortin and was developed from melanotan peptide constructs. In experimental literature, melanocortin agonists have been investigated mostly for the binding selectivity to receptors, associated signal transduction spectrum and molecular docking, mainly in terms of MC4R binding selectivity.
MC4R is a G protein-coupled receptor that activates several intracellular signaling cascades, including cAMP-dependent pathways. In laboratory studies, PT-141 has been used as a pharmacological probe to study MC receptor activation, ligand–receptor affinity, and dominantly signaling molecular elements in various downstream pathways during certain controlled scenarios [1–3].
The published reports focus on receptor interaction kinetics, dose-response signaling activity and pharmacokinetic modeling, but make no claim regarding functional or physiological consequences. These studies add to the understanding of structure–activity relationships in melanocortin-related research.
Beyond receptor-binding analyses, PT-141 has been referenced in experimental contexts examining melanocortin-related signaling networks and their interaction with intracellular regulatory pathways. Research attention has focused on how melanocortin agonists influence neuronal signaling processes, second-messenger activity, and synaptic signaling mechanisms under laboratory conditions.
Reported observations are typically confined to biochemical markers, molecular signaling intermediates, and receptor-mediated pathway activation, without attribution of behavioral, physiological, or applied effects. These studies hope to gain insight into the mechanism of pharmacology of these melanocortin receptors as opposed to making translatable conclusions [4,5].
PT-141 is a synthetic analogue of melanotan-based peptides and is employed in scientific literature as a research-grade melanocortin receptor agonist. Its investigation has centered on receptor pharmacology, intracellular signaling behavior, and molecular interaction profiling within the melanocortin system. PT-141 is supplied strictly for educational and research purposes, and acquisition is intended solely for qualified research professionals.
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide structurally related to alpha-melanocyte stimulating hormone, with a stabilised cyclic backbone that resists enzymatic degradation in cell culture environments. The peptide's structural rigidity supports reliable performance across extended in vitro assay timeframes where receptor pharmacology profiling requires sustained compound integrity.
Cell-based pharmacology research with PT-141 focuses on selective agonist activity at MC3R and MC4R melanocortin receptor subtypes (class A G protein-coupled receptors), with Gas/cAMP elevation as the primary functional readout. In vitro studies utilise heterologous expression systems in HEK293, CHO-K1, and COS-7 backgrounds to characterise binding kinetics, EC50 values, and downstream PKA/CREB phosphorylation cascades.
Element CRP supplies this product at 10mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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