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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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For this product you will need: BACTERIOSTATIC WATER For reconstitution.
Melanotan 2 is a synthetic analogue of the peptide hormone alpha-melanocyte-stimulating hormone (α-MSH). It is a heptapeptide investigated in laboratory and clinical studies due to its melanogenesis control properties—melanin production regulation processes within the cells responsible for skin pigmentation.
Initially the compound was identified in a research program targeting peptide modifications for improving in vitro molecular stability and receptor interaction profile under experimental conditions. Later scientific study has focused more on its receptor binding characteristics and at the pathway levels in melanocortin systems. Melanotan II is available strictly for research purposes only and the practice of human use of the dramatic tanning peptide Melanotan has been a concern within the scientific community.
From Pubchem
(3S,6S,9R,12S,15S,23S)-15-[[(2S)-2-acetamidohexanoyl]amino]-9-benzyl-6-[3-(diaminomethyli deneamino)propyl]-12-(1H-imidazol-5-ylmethyl)-3-(1H-indol-3-ylmethyl)-2,5,8,11,14,17-hexao xo-1,4,7,10,13,18-hexazacyclotricosane-23-carboxamide.Synonyms: Melanotan II, MT-IIMolecular Formula: C50H69N15O9Molecular Weight: 1024.2 g/molCAS Number: 121062-08-6PubChem CID: 92432
Melanotan 2 (MT-II) is a synthetic analog of the endogenous peptide alpha-melanocyte–stimulating hormone (α-MSH). In experimental research settings, MT-II is utilized as a ligand to examine melanocortin receptor subtypes, particularly MC3R and MC4R, and their association with intracellular signal transduction pathways related to systemic energy regulation. Laboratory studies typically assess receptor affinity, signaling kinetics, and downstream pathway activation under controlled conditions [1,2].
Research investigations have explored the melanocortin system in relation to intracellular signaling pathways involved in glucose transport and metabolic regulation. MT-II has been applied in experimental models to study receptor-mediated modulation of insulin-responsive signaling networks and pathway-level crosstalk. These analyses focus on molecular signaling characterization rather than physiological or functional endpoints and remain confined to preclinical research environments [3,4].
MT-II has been examined as a molecular research tool for studying melanocortin receptor activity within neuroendocrine signaling frameworks. Investigations emphasize receptor distribution patterns, ligand–receptor binding dynamics, and intracellular signaling cascades associated with melanocortin-mediated neural communication. These studies are exploratory and center on pathway mapping rather than organism-level outcomes [6–8].
As a cyclic heptapeptide, MT-II has been incorporated into laboratory studies examining melanocortin receptor activation in melanocyte-associated signaling systems. Experimental research has focused on melanogenesis-related molecular mechanisms, oxidative stress–associated signaling pathways, and intracellular regulatory processes in skin-derived cellular models. These investigations aim to clarify melanocortin-dependent signaling at the biochemical and cellular level [9,10].
Additional research applications of MT-II include studies addressing melanocortin receptor involvement in central nervous system signaling pathways. These investigations focus on receptor-level signaling dynamics, neuronal pathway modulation, and intracellular communication mechanisms under controlled experimental conditions, without extrapolation to behavioral or functional interpretations [11,12].
Melanotan 2 is currently used exclusively for research purposes. It is not approved by the FDA for clinical or therapeutic use. On our website, MT-II is available for educational and research institutions. Purchase only if you are a licensed researcher.
Melanotan II is a synthetic cyclic heptapeptide derived from the alpha-MSH sequence, featuring disulfide-bridge cyclisation that retains the conserved His-Phe-Arg-Trp pharmacophore essential for melanocortin receptor engagement. The cyclic backbone delivers superior stability in in vitro buffer systems compared with linear analogues, supporting reproducible receptor pharmacology characterisation.
In cell-based assay research, Melanotan II shows broad-spectrum agonist activity across MC1R, MC3R, MC4R, and MC5R melanocortin receptor subtypes, making it a valuable tool compound for comparative receptor pharmacology. Functional studies use cAMP detection assays in receptor-transfected CHO-K1 and HEK293 cell lines, with parallel calcium mobilisation and ß-arrestin recruitment readouts mapping the full signalling profile.
Element CRP supplies this product at 10mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
