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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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Liothyronine (T3) is a synthetic iodothyronine and structurally similar to triiodothyronine, which is derived from thyroxine and is involved in transcriptional regulation mediated by thyroid hormone receptor. In the laboratory, T3 serves as a reference molecule for investigations relating to binding of thyroid receptors, activation of nuclear receptors and the resulting gene expression associated with the cellular regulation of energy balance, thermodynamic equilibria and macronutrient metabolism at the level of biochemistry.
Liothyronine was first characterized in the mid-20th century and has been heavily investigated by both pharmacological and molecular research. Compared with thyroxine (T4), T3 has higher receptor affinity and transcriptional activity and, therefore, is well-suited for comparative studies investigating iodothyronine signaling kinetics and bioavailability. At Element CRP, liquid T3 for sale is supplied exclusively for educational and laboratory research purposes and is not intended for human or animal use, ingestion, or clinical application.
From Pubchem
IUPAC Name:(2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acidSynonyms: 3,3',5-Triiodo-L-thyronine, 6893-02-3, TresitopeMolecular Formula: C15H12I3NO4Molecular Weight: 650.97 g/molCAS Number: 15785-49-6PubChem CID: 5920
Liothyronine (T3) is studied in research settings as a high-affinity ligand for thyroid hormone receptors (TRα and TRβ), functioning as an agonist of these ligand-dependent transcription factors. Functional investigations focus on its role in regulating thyroid hormone–responsive gene networks, nuclear receptor dimerization, chromatin remodeling, and transcriptional activation via thyroid hormone response elements (TREs).
Within controlled laboratory systems, T3 is frequently used as a reference compound to examine differential receptor activation, feedback regulation within the hypothalamic–pituitary–thyroid axis, and comparative signaling cascades relative to other iodothyronines. These studies are limited to molecular and cellular observations and do not extend to physiological or clinical interpretation.
Research involving liothyronine includes examination of transcriptional programs associated with mitochondrial biogenesis, oxidative phosphorylation, and cellular metabolism. T3-mediated regulation of metabolic enzymes, transport proteins, and regulatory cofactors is analyzed to better understand thyroid hormone–dependent control of cellular energy homeostasis at the biochemical level.
These investigations utilize in vitro systems and computational modeling to characterize T3-induced changes in the expression of lipid- and carbohydrate-metabolism–related genes. Observations are confined to intracellular signaling behavior and do not imply systemic metabolic effects.
Liothyronine is used in experimental studies to examine thyroid hormone receptor expression and activity in neuronal cell populations. Research focuses on receptor localization, transcriptional regulation of neurodevelopmental genes, and interactions between thyroid hormone signaling and other nuclear receptor pathways.
Additional studies investigate the influence of T3 on neurotransmitter-related gene expression and intracellular signaling pathways in neural model systems. These investigations are mechanistic and exploratory in nature and remain restricted to non-clinical experimental settings.
Experimental research has examined the role of thyroid hormone signaling in oligodendrocyte lineage development and myelin gene expression. Liothyronine has been used as a molecular probe to investigate transcriptional regulation of myelin-associated proteins, cytoskeletal organization, and maturation-related signal transduction pathways within laboratory-based experimental models.
These studies aim to clarify thyroid hormone–dependent regulatory mechanisms within central nervous system cellular frameworks, without reference to therapeutic application or disease modification.
Liothyronine is a synthetic iodothyronine extensively characterized in molecular biology and endocrinology research. Any T3 supplied by Element CRP is strictly limited to laboratory and educational research purposes and is not intended for human or animal use, ingestion, or incorporation into pharmaceutical, dietary, or cosmetic products.
Researchers are responsible for ensuring that liothyronine is handled and utilized in compliance with applicable regulatory requirements and ethical research standards. Procurement is restricted to qualified insti
T3 Liothyronine is the synthetic form of triiodothyronine, the active thyroid hormone. As a small-molecule iodothyronine, it engages thyroid hormone receptors (THRa and THRß) — nuclear receptors regulating metabolic gene expression — and supports reliable behaviour across in vitro thyroid pharmacology research applications.
Cell-based research with T3 Liothyronine examines THR binding affinity, ligand-dependent transcriptional regulation, and metabolic gene expression in hepatocyte, cardiomyocyte, and adipocyte cell models. Standard readouts include TRE-driven reporter gene assays, target gene expression profiling (DIO1, MCT8, UCP1), and comparative pharmacology against other thyroid hormone analogues.
Element CRP supplies this product at 200mcg/mL × 30mL. USA-manufactured via chemical synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Pre-mixed liquid solution in 30mL or 60mL bottle with dropper; ready for laboratory use. Store at 15-25°C, away from direct light.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
