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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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IGF-1 LR3 (Insulin-Like Growth Factor-1 Long Arg3) a recombinant human polypeptide analog of insulin-like growth factor-1 (IGF-LR3) that belongs to the family of polypeptide hormones which play a significant role in receptor mediated cellular signaling; stimulant for cell growth, proliferation and differentiation through its binding with the type 1 IGF receptor. IGF-1 is produced in the circulation as a direct response to growth hormone and participates in intracellular pathways that on metabolism, cellular function, and intracellular pathways in experimental model systems.
IGF-1 LR3 is a synthetic analog of human IGF-1 that differs from the wild-type protein by 13 amino acids at the N terminus and substitution arginine for glutamic acid at position three, which leads to changes in receptor-binding kinetics and prolonged biologic activity in laboratory studies. This variant is utilized exclusively for in vitro studies and controlled research applications. IGF-1 LR3 is not approved for therapeutic or clinical use and is available solely for qualified research and educational purposes.
Synonyms: Insulin-like growth factor long chain R3, Long-(arg3)insulin-like growth factor-iMolecular Formula: C400H625N111O115S9Molecular Weight: 9117.60 g/molSequence: MFPAMPLSSL FVNGPRTLCG AELVDALQFV CGDRGFYFNK PTGYGSSSRR APQTGIVDEC CFRSCDLRRL EMYCAPLKPA KSACAS Number: 143045-27-6PubChem SID: 381123731
IGF-1 LR3, an insulin-like growth factor-I recombinant analog, has been used in synergy assays as a modulator of myoblast proliferation, differentiation, and cytoskeleton remodeling-regulated intracellular signaling pathways. Changes in receptor structure affect ligand binding kinetics and downstream molecules relevant to anabolic signaling and tissue structural regulation. In laboratory and in vitro settings, IGF-1 LR3 modulates protein turnover and cellular metabolism while exhibiting anabolic effects under controlled conditions [1].
The N-terminal extension and amino acid substitution in IGF-1 LR3 confer altered affinity for native receptors and regulatory binding proteins. In experimental models, these modifications are associated with modulation of cell proliferation, myogenic protein synthesis, and intracellular signaling networks related to hypertrophic processes. IGF-1 LR3 demonstrates enhanced potency compared to native IGF-1, providing a framework for mechanistic studies of muscle growth and tissue remodeling [2,3].
IGF-1 LR3 has been assessed in controlled experimental systems for interactions with glucose-regulatory pathways, receptor-mediated signaling networks, and cellular energy homeostasis. Reduced affinity for IGF-binding proteins affects peptide accessibility to target receptors under laboratory conditions. These interactions may influence metabolic signaling cascades, glucose transport mechanisms, and intracellular bioenergetics, offering mechanistic insight into peptide-mediated metabolic modulation [4,5].
In vitro studies have investigated IGF-1 LR3 for its effects on signaling pathways mediating osteogenic differentiation, extracellular matrix deposition, and skeletal repair. Interaction with receptor-mediated effectors and intracellular pathways indicates potential modulation of tissue turnover, mineralization, and extracellular matrix integrity under controlled laboratory conditions [6,7].
IGF-1 LR3 has been studied for its effects on intracellular signaling networks involved in neuronal survival, synaptic plasticity, and neurotrophic factor-mediated pathways. In experimental models, activation of these networks modulates excitatory receptor dynamics, kinase-mediated signaling, and synaptic transmission, supporting mechanistic research in neurobiology [8,9].
IGF-1 LR3 is a structurally modified recombinant analog of insulin-like growth factor-1 with enhanced stability and altered receptor interactions in laboratory settings. Its effects on myogenic, osteogenic, metabolic, and neurobiological signaling pathways have been evaluated exclusively in experimental systems. IGF-1 LR3 is restricted to research and educational purposes and is not approved for clinical or therapeutic use. Element CRP supplies IGF-1 LR3 exclusively to licensed research institutions.
IGF-1 LR3 is a synthetic 83-amino-acid analogue of insulin-like growth factor 1, featuring an Arg-to-Glu substitution at position 3 and an additional N-terminal extension that reduces binding to IGF-binding proteins and extends in vitro half-life. The structural modifications support sustained compound activity across long incubation periods.
Cell-based research with IGF-1 LR3 investigates engagement at the IGF-1 receptor (IGF-1R), a receptor tyrosine kinase, in myocyte and hepatocyte cell models. Standard functional readouts include autophosphorylation of the receptor, downstream PI3K/Akt pathway activation, and MAPK cascade engagement through phospho-specific antibody detection.
Element CRP supplies this product at 1mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
