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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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For this product you will need: BACTERIOSTATIC WATER For reconstitution.
Hexarelin (also known as examorelin) is a type of synthetic hexapeptide belonging to the family of growth hormone-increasing peptides that resembles ghrelin. Endogenous ghrelin is an endocrine factor secreted from the stomach called a functional ligand for the growth hormone secretagogue receptor subtype 1a (GHS-R1a); this receptor system has been actively studied with respect to its roles in metabolic regulation, signal transduction pathways, and endocrine regulations.
Hexarelin, a hexaptide with 6 amino acids, was developed in the course of early secretagogue work aimed at lowering off-target endocrine activity and increasing selectivity for receptors. Preliminary mechanistic characterizations described sustained receptor interaction and modified pharmacodynamic behavior relative to earlier analogues, contributing to its continued evaluation within growth hormone–associated signaling research. Hexarelin is not approved for clinical application and is distributed solely for research and educational use.
From Pubchem
IUPAC Name: L-histidyl-2-methyl-D-tryptophyl-L-alanyl-L-tryptophyl-D-phenylalanyl-L-lysinamideSynonyms: Examorelin, Examorelin [INN]Molecular Formula: C47H58N12O6Molecular Weight: 887.0 g/molSequence: HXAWFKCAD Number: 140703-51-1PubChem CID: 6918297
Hexarelin has been studied for its effects on cardiomyocytes, hepatocytes, and pancreatic islet cells, which are components of metabolic control systems such as glucose homeostasis and lipid metabolism. Preclinical animal studies have shown that hexarelin can influence markers of adipocyte differentiation and lipid profiles in hepatic and plasma tissues.
In vitro and ex vivo models indicate that hexarelin can modulate intracellular signaling pathways involved in energy sensing, lipid utilization, and insulin-responsive mechanisms. These findings support its use as a molecular probe to explore metabolic physiology and cellular nutrient-sensing networks [1].
Hexarelin has been examined for its interactions with cardiovascular receptor systems and related signaling pathways. Research evaluating binding to cardiac membrane proteins, including GHS-R1a and CD36 homologues, has shown ligand-dependent changes in contractile and perfusion parameters.
Experimental studies also reported modifications in oxidative stress markers, endothelial nitric oxide synthase (eNOS) expression, and extracellular matrix remodeling in cardiac tissue. Additional investigations have demonstrated effects on calcium fluxes, action potential kinetics, and cardiomyocyte anti-apoptotic signaling, supporting the use of hexarelin as a molecular tool for studying cardiomyocyte and vascular endothelial function [2–5].
Laboratory studies have employed hexarelin to investigate the growth hormone/IGF-1 axis and myocellular metabolic regulation. Research indicates modulation of protein turnover, myofibrillar organization, and mitochondrial function in cellular and tissue-based models.
Hexarelin influences signaling nodes involved in bioenergetics, inflammatory cascades, and cellular differentiation, demonstrating its utility as a mechanistic probe in skeletal myotropic pathways and GH-responsive metabolic networks [6].
Mechanistic understanding of hexarelin is currently limited to preclinical and in vitro models focusing on metabolic, cardiovascular, and myotropic signaling axes. Its pharmacodynamics and receptor selectivity are actively studied in laboratory research. Hexarelin is not FDA-approved for clinical use and is intended solely for research and educational purposes. At Element CRP, researchers can buy hexarelin exclusively for laboratory investigation, restricted to licensed research personnel.
Hexarelin is a synthetic hexapeptide growth hormone secretagogue with structural features optimised for engagement at the ghrelin receptor and CD36 scavenger receptor. The peptide's stable conformation supports reproducible behaviour in cell-based receptor pharmacology and signalling pathway research.
Cell-based pharmacology research with Hexarelin examines agonist activity at GHSR-1a in pituitary and cardiomyocyte cell models, with calcium mobilisation and PLC pathway activation as primary readouts. Additional in vitro work characterises its binding to CD36 and downstream effects on the IGF-1 axis through cell-based functional assays.
Element CRP supplies this product at 5mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
