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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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For this product you will need: BACTERIOSTATIC WATER For reconstitution.
GHK-Cu, an abbreviation for gly-cis-his-lys copper complex, is a combo of a tripeptide that includes glycine, histidine and lysine. It is endogenously found in human plasma, saliva and urine, and its concentration falls with age. Scientific investigation has determined its participation in multiple biological and cellular processes, such as tissue remodeling pathways, angiogenic activity protein synthesis, mechanisms associated with collagen and cellular regeneration in experimental models.
GHK-Cu was first isolated from plasma albumin by Loren Pickart in 1973. Subsequent studies further investigated its role in cellular signaling and tissue-related research applications. Since its discovery, it has attracted interest from researchers and the cosmetic science community for its biological activity in laboratory settings. GHK-Cu is not approved by the FDA. On our website, GHK-Cu for sale is offered strictly for research and educational purposes only.
From Pubchem
IUPAC Name: 6-amino-2-[[2-[(2-aminoacetyl)amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid;copper Synonyms: SCHEMBL2243002, [Lysine, glycylhistidyl-, monocopper salt] Molecular Weight: 403.92 g/molMolecular Formula: C14H24CuN6O4 Sequence: GEPPPGKPADDAGLV PubChem CID: 342538
GHK-Cu has been studied in laboratory research for its interactions with pathways involved in skin function, including extracellular matrix organization, keratinocyte activity, and pigmentation. Observations have included associations with collagen-, elastin-, and glycosaminoglycan-related mechanisms under controlled experimental conditions [1].
Laboratory studies have also evaluated GHK-Cu–containing formulations in vitro to examine effects on skin-related markers, such as cell proliferation, extracellular matrix pathways, and signalling under defined research conditions [2].
Experimental wound-related models have been used to assess GHK-Cu–encapsulating liposomes, investigating endothelial cell proliferation, expression of cell cycle molecules (CDK4, CyclinD1), angiogenesis-associated proteins, and fibroblast growth factors [3].
Additionally, inflammation-related pathways have been explored in vitro, including modulation of cytokine signalling, such as IL-16 induced by TNF-alpha in skin fibroblasts under laboratory conditions [4].
GHK-Cu has been studied in hair follicle biology and structural control of the hair under laboratory conditions. As a member of the various pathways associated with angiogenesis, this peptide also has been tested for effects on blood vessel development and nutrient delivery in follicular microenvironments. In vitro investigations studied its effects on cellular processes related to the physiology and structure of the follicle [5].
A study was conducted on safety and efficacy of 5-aminolevulinic acid (5-ALA) and glycyl-histidyl-lysine (GHK) in subjects with pattern hair loss. The test samples were administered once-a-day for six months and the joint capacities of 45 male volunteers, treated with the placebo or a test formulation (100 mg/ml and 50 mg/ml), were determined. The hair count change differences were found between groups with higher test values in the 2.5% group as compared to the 1.25% and placebo group at study conditions [6].
GHK-Cu has been evaluated in vitro for its potential to influence signaling mechanisms associated with nociception. Observations suggest its interactions with L-lysine–related pathways may impact molecular cascades associated with sensory modulation under experimental conditions [7].
GHK-Cu has been shown to modulate gene expression patterns under experimental laboratory conditions. Analyses reveal the impact on signaling networks that contribute to tissue remodeling, responses to oxidative stress, programmed response to cell death and autophagy. Large scale transcriptomic screens have identified potential GHK-Cu effects on a variety of gene networks, supporting the use of this compound to study molecular mechanisms associated with aging-related gene regulation and cell signaling [8].
Experimental studies focused on the impact of GHK-Cu have been performed to study in vitro angiogenic signaling, inflammatory pathway, cell integrity. Studies are centered on molecular and cellular responses that are relevant to neural microenvironments and vessel interactions [9].
GHK-Cu has been explored under experimental conditions for its influence on pathways associated with behavior and cellular signaling. Laboratory experiments were meant to provide insights into mechanisms of neurochemical and signaling responses, as opposed to whole-organism outcomes [10].
GHK-Cu is a copper complex of a tripeptide of the human plasma, saliva and urine. Its effect on molecular signaling, angiogenesis, collagen synthesis and tissue remodelling have been studied in laboratory. Element CRP offers GHK-Cu strictly for laboratory and educational research, with no clinical or human/animal application intended.
GHK-Cu (copper tripeptide-1) is a synthetic naturally-occurring tripeptide complex with the sequence Glycyl-L-Histidyl-L-Lysine bound to a copper(II) ion. The metallopeptide structure supports reliable behaviour in cell culture systems and serves as a research tool for extracellular matrix and skin cell biology investigations.
Cell-based research with GHK-Cu examines its activity in extracellular matrix protein expression studies using fibroblast cell line models, including effects on collagen, elastin, and glycosaminoglycan synthesis pathways. In vitro studies also characterise the compound's effects on copper-dependent enzyme function and cellular antioxidant pathway responses.
Element CRP supplies this product at 50mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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All products on this site are for Research, Development use only. Products are Not for Human consumption of any kind. The statements made within this website have not been evaluated by the US Food and Drug Administration. The statements and the products of this company are not intended to diagnose, treat, cure or prevent any disease.
Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
