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Product Usage: This PRODUCT IS INTENDED AS A RESEARCH CHEMICAL ONLY. This designation is allowed to use of research chemicals strictly for in vitro testing and laboratory experimentation only. All product information available on this website for educational purpose only. Bodily introduction of any kind into humans and animals is strictly forbidden by law. This product should only be handled by licenced qualified professionals. This product is not a drug, food, or cosmetic and may not be misbranded, misused as a drug, food and cosmetic.
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5-Aminoimidazole-4-carboxamide ribonucleoside (AICAR), an unnatural base analogue which is structurally related to adenosine monophosphate. With regard to the chemical classification, AICAR is often referred to by biochemists because it is closely related to naturally produced purine derivatives in the cells and its capability of influencing nucleotide synthesis.
Within controlled laboratory settings, AICAR is utilized as a molecular reference compound for examining AMP-associated signaling architecture, intracellular nucleotide flux, and enzyme-linked regulatory frameworks. Its relevance in experimental systems is primarily attributed to its interaction with pathways associated with AMP-responsive kinases, purine salvage mechanisms, and ATP-linked molecular equilibria at the cellular level. Ongoing investigative work focuses on characterizing its biochemical behavior, kinase interaction profiles, and receptor-adjacent signaling parameters under defined in-vitro conditions.
At Element CRP, AICAR is supplied strictly for laboratory research and analytical investigation only. This material is not intended for human or animal use, and no clinical, therapeutic, diagnostic, or physiological applications are expressed or implied.
From Pubchem
IUPAC Name:5-amino-1-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]imidazole-4-carboxamideSynonyms: MFCD00869751, 37642-57-2Molecular Formula: C9H14N4O5Molecular Weight: 258.23 g/molCAS Number: 37642-57-2PubChem CID: 2669340
5-Aminoimidazole-4-carboxamide riboside (AICAR) is a synthetic nucleoside analogue commonly referenced in biochemical research due to its structural relationship with adenosine monophosphate (AMP). Within controlled experimental systems, AICAR is utilized as a molecular probe for examining AMP-responsive signalling frameworks and kinase-associated regulatory networks [1].
Laboratory investigations involving AICAR primarily focus on its interaction with AMP-sensitive enzymatic cascades, intracellular nucleotide equilibrium, and signal transduction nodes associated with energy-linked molecular sensing. These evaluations are conducted under defined analytical conditions to characterize pathway engagement, signalling flux, and downstream molecular interactions without attribution to physiological outcomes [2].
In research environments, AICAR has been employed as a reference compound to explore signalling networks associated with carbohydrate-related molecular processing and kinase-mediated regulatory systems. Analytical models have examined how AMP-linked pathway modulation corresponds with alterations in intracellular signalling intermediates involved in substrate handling and metabolic signal integration [3].
Such investigations are limited to biochemical pathway mapping and signal correlation analysis within controlled systems, emphasizing molecular interactions rather than functional or organism-level interpretations [4].
AICAR has been incorporated into in-vitro experimental platforms to evaluate signalling pathways related to cellular growth regulation, stress-associated signalling, and kinase-dependent transcriptional modulation. These studies focus on pathway architecture, signal propagation, and regulatory feedback loops observed within transformed and non-transformed cellular systems [5].
Analytical observations include modulation of signalling intermediates associated with programmed cellular turnover, transcription factor activity, and mitochondrial-linked regulatory pathways. These findings are interpreted strictly within the context of molecular signalling characterization and do not imply functional, therapeutic, or biological outcomes [6].
Research involving AICAR has also examined its role as a biochemical tool for studying AMP-activated signalling networks related to cellular energy distribution, structural remodelling signals, and matrix-associated molecular interactions. Experimental systems assess how AMP-responsive kinase activity correlates with changes in intracellular signalling markers involved in structural organization and substrate utilization [7].
These analyses are confined to controlled laboratory conditions and are intended solely to advance understanding of kinase-associated signalling topology and intracellular communication dynamics [8].
AICAR is a synthetic analogue of adenosine monophosphate (AMP) frequently referenced in biochemical and molecular research as a tool compound for examining AMP-associated kinase signalling systems. Its use in laboratory settings is limited to analytical investigation of intracellular signalling architecture, nucleotide-related regulatory mechanisms, and pathway-level molecular interactions.
AICAR is classified strictly as a research material. It is not approved for human or animal use, and no clinical, diagnostic, therapeutic, or physiological applications are expressed or implied.
At Element CRP, AICAR is supplied exclusively for laboratory research and analytical investigation by qualified professionals.
AICAR (5-aminoimidazole-4-carboxamide ribonucleotide) is a synthetic adenosine analogue and AMP mimetic with a small-molecule structure that supports excellent solubility and stability in standard cell culture media. The compound functions as a research probe for direct AMP-activated protein kinase (AMPK) activation in cell-based metabolic pathway studies.
Cell-based research with AICAR examines AMPK activation through allosteric binding at the gamma subunit, with downstream phosphorylation of acetyl-CoA carboxylase (ACC) at Ser79 as a standard pathway readout. In vitro studies in skeletal muscle cell lines, hepatocytes, and adipocyte models characterise its effects on metabolic enzyme phosphorylation cascades.
Element CRP supplies this product at 50mg per vial. USA-manufactured via solid-phase peptide synthesis and verified at 99%+ purity by HPLC and Mass Spectrometry. Reconstitution with bacteriostatic water required. Store lyophilised at -20°C; stable for 24 months.
WARNING: For research use only. Not for human or animal consumption. Not intended to diagnose, treat, cure, or prevent any disease. For use by qualified research professionals only.
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Element CRP is a chemical supplier. Element CRP is not a compounding pharmacy or chemical compounding facility as defined under 503A of the Federal Food, Drug, and Cosmetic act. Element CRP is not an outsourcing facility as defined under 503B of the Federal Food, Drug, and Cosmetic act.
